comparing the effect of glucosamine and glucosamine with alendronate in symptomatic relieve of degenerative knee joint disease: a double- blind randomized clinical trial study

background: degenerative joint disease (djd) is the most common joint disease in human beings. previous studies have explained that glucosamine is preferred as placebo and in efficacy compared with nsaid’s in treatment of patients’ knee osteoarthritis. alendronate was used to treat osteoporotic patients and its efficacy was established. objectives: the aim of this study was to compare the efficacy of administration of glucosamine alone and its combination with alendronate in osteoarthritis of the knee. patients and methods: the study included 130 patients with osteoarthritis who randomly received glucosamine alone (group ii) (500mg tds), or combination of glucosamine (500mg tds) and alendronate (70mg weekly) (group i) for 12 weeks. patients were evaluated on 1, 3, 6 and 12 weeks after beginning the treatment to evaluate efficacy of each treatment. results: statistically, there was no significant difference in pain index (p > 0.05) but in the two groups the mean of pain index decreased in a similar fashion. the stiffness index in combination treatment group (group i) decreased more than glucosamine group (group ii) (p < 0.05). the function of joints in combination treatment group (group i) improved after 12weeks. the bone mineral density (bmd) at 12weeks in combination therapy group improved. conclusions: combination therapy of glucosamine and alendronate indicated significant improvement of stiffness, function, bmd of osteoarthritis compared with glucosamine alone but there was no statistically significant decrease in pain index. it can be concluded that the combination of glucosamine and alendronate provide better and more rapid improvement in patients with osteoarthritis.